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From Super-wiki
→How to Kill the Supernatural
heres what i got so far, but additions, edits or corrections would be great.
Spirit - Salt and Burn Remains or Otherwise Put at Rest(various episodes but i can list all of them if i need to)
Wendigo - Burn(1.02 Wendigo. Dean shoots it with a flare gun)
Demon - Exorcism(various episodes but i can list all of them if i need to)
Shapeshifter - Silver Bullet or Blade(1.06 Skin, 2,12 Nightshifter. Dean shoots the first one with a silver bullet and Dean stabs the second with a silver letter opener)
Rawhead - Electrocution(1.12 Faith. Dean electrocuts it with a taser)
Reaper - N/A(1.12 Faith, 2.01 In my time of Dying. in Faith Dean says you cant kill death and in 2.01 Sam says if its here naturally theres no way to stop it)
Shtriga - Consecrated Wrought Iron Rounds While Feeding(1.18 Something Wicked. Dean shoots it while it feeds on Sam)
Vampire - Beheading(1.20 Dead Mans Blood, 2.03 Bloodlust, 3.07 Fresh Blood.)
Rakshasa - Brass Blade(2.02 Everybody loves a clown. Sam kills it with a brass pipe from an organ)
Zombie - Nail to Grave Bed(2.04 Children shouldn't play with dead things. Dean nails her to her coffin)
Trickster - Stake Dipped in the Blood of a Victim Through the Heart(2.15 Tall Tales. Dean stabs it although it was only an apparition and not the real thing leaving the trickster alive)
Werewolf - Silver Bullet to the Heart(2.17 Heart. Dean kills the sire werewolf and Sam kills Madison)
Djinn - Silver Blade Dipped in Lamb's Blood(2.20 What is and what should never be. Dean stabs in as it attacks Sam)
Changling - Burn also Burning Mother Will Kill Children(3.02 The kids are alright. Sam burns the mother )
GODS-
Vanir - Burn Sacred Tree(1.11 Scarecrow. Emily burns the tree after escaping the scarecrow)
(Christmas one) - Evergreen Stake(3.08 A very supernatural christmas. Sam kills one and Dean kills one with branches from a christmas tree
CURSES-
Native American Bugs - N/A(1.08 Bugs. In the episode Dean says You dont break the curse, you get out of its way)
Rabbit's Foot - Burn in Cemetary with Cayenne Pepper and Bone Ash(3.03 Bad day at black rock. Sam and Dean destroy it after "convincing" Bela to hand it over)
im unsure of the name of the god in 3.08 but ive read it be something like Holnacar or Hold Nickar.
