Bobby attempts to sneak up on Castiel, after Dean has stabbed him in the chest. Without looking, Castiel grabs Bobby's weapon and uses it to swing him around. He then touches Bobby on the forehead with two fingertips, causing Bobby to be rendered unconscious and crumple to the ground.
After Dean reveals himself to a street preacher talking about the Apocalypse, Castiel appears and touches the preacher, causing him to fall to the ground unconscious, before he drags Dean into the nearby alley and beats him up. Angry that Dean has given up, he unclenches his fist and touches Dean's shoulder, knocking him out.
When confronting a boy named Aaron Birch, who had a piece of the Staff of Moses, Castiel renders his father, Darryl, unconscious with a touch. After learning Aaron sold his soul for the piece, Castiel presses his fingers to Aaron's forehead, rendering him unconscious.
Believing himself the new "God", Castiel confronts a reverend whose views he deems hypocritical. When a parishioner attempts to stop Castiel, he renders him unconscious, breaking the church pew and forcing his body down.
Ketch's hunt for Lucifer brings him to Missouri, where he crosses paths with the Winchesters and Castiel. He tells them he is going after Lucifer for the good of humanity; the Winchesters don't buy his reasoning and upon Ketch offering a team-up to go after Lucifer, his proposal is rejected by Castiel who renders him unconscious with a touch to the forehead.