Term coined by fandom for Dean's amulet, given to a teenage Dean by an 8-year-old Sam in 3.08 A Very Supernatural Christmas. It was very important to Dean, who wore it always until he discarded it in 5.16 Dark Side of the Moon.
First recorded use was after the events of 5.02 Good God, Y'All, in which Castiel took the amulet from Dean, because it will burn hot in God's presence. This led fans to speculate that the amulet symbolizes Sam's love for Dean, which would make the amulet "burn hot in God's presence."
A replica Samulet appears in the musical in 10.05 Fan Fiction. After Marie says Dean should never have thrown it away, he states he doesn't need it to remind him how he feels about Sam. However, at the end of the case, when she gives it to him, he keeps it and hangs it from the Impala's rearview mirror. It is later seen in Sam's Memory Box in 11.11 Into the Mystic.
In 11.20 Don't Call Me Shurley, God, in the form of Chuck Shurley shows Metatron the amulet, telling Metatron that he'd never believe where it's been the whole time. God reveals that he shut off the amulet's ability to detect him so the Winchesters and Castiel couldn't find him. At the end of the episode, Dean pulls the amulet out of Sam's pocket; it's glowing and it finally leads them to God. In the next episode, Dean puts it in his pocket after God transports them back to the Bunker.