A portal is doorway that exists between different realms or planes of existence. They are usually hidden and often guarded with magic and rituals.
Its a tear in space and time... a doorway to another world.
As Jack the Nephilim is close to being birthed, his power surges through his mother and is released, causing a puncture in the fabric of the universe and opening a door to Apocalypse World, an alternate version of Earth. Castiel, Sam, and Dean travel back and forth through it, ultimately using it to trap Lucifer on the other side. The portal is closed due in part to Crowley sacrificing himself as the final ingredient for the ritual to seal the rift. The portal fully closes as Jack is born, just as Lucifer is knocked back into it and pulls Mary through to Apocalypse World with him.
Fandom nicknamed the portal the "glowy space vagina."
There are a number of Hell Gates, also known as Devil's Gates, which are portals between Hell and Earth. When opened they allow demons passage to Earth. One of the major gates is the Devil's Gate in Wyoming which Samuel Colt built a huge devil's trap around to prevent demons accessing it. There was a church at each point and the sides of the pentacle were made of iron railroad lines. Azazel planned to open the Gate to release demons to use in a war against humanity.
As the devil's trap prevents him from getting to the Gate, he uses Jake Talley -- one of the Special Children to cross into it and unlock the Gate using the Colt as the key. When the door is open the blast of energy lights up the surrounding railways and blows up at least one of the churches, which significantly weakens the devil's trap and allows the Yellow-Eyed Demon to enter. Hundreds of beings, including demons and spirits, escape from Hell before Bobby and Ellen manage to close the gate. John Winchester is among those to escape through the gate.
There is also a secret "backdoor" entrance to Hell located in Purgatory that is used by rogue reapers as a means of ferrying souls around. The location of the portal can be found by following a specific stream to where three trees meet as one. Where they meet, there are rocks, and between the rocks is the portal.
The second ritual was performed by dragons as means to bring Eve, the Mother of All Monsters, to Earth. This ritual came from an ancient manuscript; it requires a virgin sacrifice to serve as an Earthly vessel for Eve, the blood of the summoner, and an incantation in Latin. Once the first line of the incantation is spoken, a doorway to Purgatory will open, at which point the blood of the summoner must be bled into it, and the virgin sacrifice thrown into the portal.
The third ritual was acquired by Castiel and Crowley through the torture of Eleanor Visyak. This ritual requires a special sigil painted in the blood of a virgin, and a native of Purgatory. The final part of the ritual requires a Latin incantation to be recited on the night of a lunar eclipse.
As there are ways into to Purgatory, there is also a way out designed specifically for a human, if one was to ever end up there. The portal is located atop a cliff; once a human steps through, they will be transported to the 100-Mile Wilderness in Maine.
After Metatron expelled all the angels and locked the Gates of Heaven, he created a piece of spell work that allowed him to come and go from Heaven to Earth. The spell simply requires a specific sigil - Metatron's Cube - to be drawn. Once done, it will create a doorway into Heaven.
The portal is currently located in a playground. Prior to Metatron's reign coming to end he was known to move location of the entrance around. It is always guarded by one or two angels, who draw the Metatron's Cube sigil in a sandbox. As Metatron's spell has not been reversed, even after his capture, this is currently the only method by which angels can access Heaven from Earth.
In the Abrahamic religions, the idea of a "stairway to Heaven" is known as Jacob's ladder.
Access to Oz can be achieved through the use of one of the six keys forged in Oz. If the key is used on any door, said door will turn into a doorway to Oz. Conversely if the key is used in Oz, it will become a doorway to Earth. Entrance to Oz can also be achieved through natural disasters like tornadoes, whirlpools, or the eye of a hurricane.
The Wizard of Oz was also shown to be powerful enough to create a portal from Oz to Earth through the use of magic, using a mirror as a conduit.
French Mistake World
Balthazar appears gives Sam and Dean a key to an alternate universe where he has stored the stolen angelic weapons of Heaven, which will help Castiel to retain control in Heaven. However, this is a ruse. The boys find a world where their lives are the basis of a TV show, and magic and the supernatural don't exist. The portal is a window in Bobby's house on one side, and a window in the TV set of Bobby's house on the other.