Ectoplasm

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Ectoplasm

A dense bio-energy that makes the materialisation of ghosts possible. The term ectoplasm was used in a similar sense in the 1984 film, Ghostbusters.

Pad of Definitions (2.06 No Exit), Official Website

in Supernatural, ectoplasm appears as a viscous black liquid.

In 2.06 No Exit, ectoplasm is generated by the spirit of Dr. H.H. Holmes. Dialogue between Sam and Dean indicate that the spirit would need to be extremely powerful (and pissed off) in order to create ectoplasm.

In 4.13 After School Special, ectoplasm leaks out of the eyes and ears of the students possessed by Dirk McGregor's ghost.

In 7.22 There Will Be Blood when Bobby posseses Louise, ectoplasm leaks from her eye.

In 8.06 Southern Comfort, the spectre of Vance Collins leaks green ectoplasm all over the place when possessing people to kill people they have a grudge against. The green ectoplasm allows them to identify Vance as a spectre from Bobby's Journal.