Drugs

Dean: Uh, should we dim the lights and sync up Wizard of Oz to Dark Side of the Moon? Sam: Why? Dean: What did you do during college? – Sam and Dean, 3.10 Dream a Little Dream of Me

The theme of addiction is recurrent throughout Supernatural, and recreational drugs are no exception. Though alcohol is the drug of choice for hunters, some characters in the series are shown turning to marijuana and prescription drugs as their own form of escapism. While no characters are explicitly shown smoking or snorting any illegal substances in the series, Dean especially has a running commentary on drugs, both in joking reference to other characters's paraphernalia and by alluding to his own history with illegal substances.

Episodes

2.04 Children Shouldn't Play with Dead Things

"Are you high?" Sam asks Dean sarcastically, and Dean takes a moment to seriously consider the possibility before Sam moves on.

2.05 Simon Said

In Andy's van, Sam and Dean find a very large piece of drug paraphernalia, which Dean refers to as "Moby Dick's bong."

2.10 Hunted

Laughing, Sam asks where he and Dean are headed next. Dean jokingly suggests Amsterdam, and when Sam objects, Dean responds, "Come on, man! I hear the coffee shops don’t even serve coffee." The coffee shops in Amsteradam do, of course, serve coffee. They also legally serve cannabis.

2.20 What Is and What Should Never Be

In what appears to be an alternate reality in which Mary is still alive, Dean is acting strange. Sam asks what's gotten into Dean that he seems so happy and affectionate towards his family, saying, "I mean this whole warm, fuzzy ecstasy-trip thing." Dean brushes it off as just being happy about Sam's engagement to Jessica, who is also still alive. Later in the episode, Dean struggles to differentiate whether his new reality is in fact a djinn's spell. He theorizes, "Maybe [the djinn] gives us some kind of supernatural acid and then just feeds on us slow." To which (a fake) Sam argues back, "I'm real. This is not an acid trip. I'm real, and that thing is gonna come down here and kill us for real. Now, please—" Because Sam is actually a creation of Dean's wish, both drug references that Sam makes in this episode are actually Dean's own imagining.

2.21 All Hell Breaks Loose: Part One

When Sam meets up with Andy Gallagher at Cold Oak, he asks Andy what the last thing he remembered was before waking up there. Andy replies, "My fourth bong load."

3.08 A Very Supernatural Christmas

As Sam and Dean hunt for an "Evil Santa," they follow the Santa from a Christmas village to his home. They enter armed, but find a disheveled "Santa" watching Christmas-themed porn and smoking a large bong with a bottle of liquor in hand.

3.10 Dream a Little Dream of Me

Because of the use of African Dream Root in this episode, there are frequent references to drugs and stoner culture, including Dean agreeing to know what a bad acid trip is like (and then denying it when he remembers he's pretending to be FBI), and the header quote on this page in which Dean references The Dark Side of the Rainbow, typically experienced while high.

4.07 It's the Great Pumpkin, Sam Winchester

When Sam and Dean go to interview Don Harding, Dean sees a student named Justin putting a large bong-shaped clay piece into a kiln. "Now that brings back memories," Dean remarks.

4.10 Heaven and Hell

When Anna tells Dean she can take her grace back in and become an angel again, Dean responds: "So what, you're just gonna take some divine bong hit and Shazam, you're Roma Downey?"

4.21 When the Levee Breaks

Throughout the series, Sam's demon blood addiction is referred to using terms traditionally reserved for drug addictions. In this episode, Sam is trapped in Bobby's panic room and forced to go without the demon blood in what Bobby refers to as "demon-detox" and going "cold turkey." The symptoms Sam experiences as a result of being cut off from the demon blood are also similar to the symptoms of withdrawal from hard drugs, including sweating, insomnia, seizures, paranoia, and hallucinations.

5.04 The End

In Zachariah's vision of a post-apocalyptic future, Castiel is no longer an angel and has turned to sex, alcohol, and prescription amphetamine as a means of escapism. Upon meeting him, Dean asks if Castiel is stoned. Castiel's response is, "Generally, yeah."

5.11 Sam, Interrupted

In order to get admitted to a psychiatric hospital for a case, Dean and Sam tell a doctor there about the apocalypse. Sam says he blames himself, but Dean insists it was Ruby's fault, along with the demon blood Sam was drinking. "My brother's not evil," Dean concludes, smiling and shrugging. "He was just... high." Later on in the episode, Sam attacks the doctor believed to be a monster and is sedated. "They gave you something?" Dean asks, to which Sam struggles to reply, "They gave me... everything. It's spectacu--lacular." He laughs, and Dean remarks that Sam always was a happy drunk.

6.14 Mannequin 3: The Reckoning

After Sam suffers through resurfacing memories of Hell, Dean offers him food, caffeine... and a bottle of prescription pills that Dean refuses to identify. Sam declines.

6.21 Let It Bleed

Lisa and Ben are kidnapped, and Dean is torturing demons for information. Sam asks him to take a break by saying, "Look, man. You - you're running on what, uh, whisky and - and coffee and whatever else you're taking," implying drug use beyond alcohol and caffeine. Dean answers simply, "Yeah, and?"

8.01 We Need to Talk About Kevin

Dean angrily rebukes Sam with a drug-laden non sequitur, "The rules are simple, Sam. You don’t take a joint from a guy named Don, and there’s no dogs in the car!"

8.04 Bitten

There is a large bong in Michael Wheeler and Brian Wilcox's house. After hearing Sam and Dean speculate that the creature responsible for recent deaths may be a Mayan god, Michael (who has become a werewolf) holds the bong aloft and declares: "I am a golden god. I am a golden god!"

8.14 Trial and Error

Kevin is left on his own to translate the demon tablet, and is already shown to be taken aspirin and caffeine regularly. When Dean and Sam drop by, Dean cheerfully gives Kevin two more bottles to add to the mix, along with a friendly slap on the arm. "The, uh, blue ones are for the headaches, and the greens are for pep. Don't O.D." After they're out of earshot, Sam questions Dean, but Dean's response is dismissive. "Sam, we are on the one-yard-line. It is time to play through the pain."

9.13 The Purge

Dean is drugged to unconsciousness after eating salted-caramel pudding laced with "supplements." Dean looks at the pills labelled as supplements and identifies them as roofies, leading Sam to question, "How do you know what roofies look like?" Dean combats, "How do you not know?"

11.07 Plush

A jailed killer is wearing a mascot head that can't come off, and he won't speak. Disguised as an FBI agent, Dean tries to coax the suspect into talking by baiting him. "So what happened, pal? Hmm? What, you drop too much molly, superglue your mask to your head, get paranoid, stab a guy? I've been there."

11.11 Into the Mystic

While investigating a nursing home for a case, Sam and Dean discover that one of the residents has been stealing Viagra from his neighbors. "A real dick move, huh?" Dean says, before pocketing the bottle for himself.

11.17 Red Meat

In a desperate attempt to save Sam, Dean overdoses on a mixture of different pills to kill himself temporarily in order to speak with Billie the Reaper.