Dr Sexy M.D.
Sam: What are you watching?
Dean: A hospital show - Dr. Sexy, M.D.. I think it's based on a book.Sam: When did you hit menopause?
– Sam and Dean, 5.08 Changing Channels
Dr. Sexy, M.D. is the name of a fictitious hospital drama, based on a series of books, that has featured in Supernatural. It is a hospital drama set at Seattle Mercy Hospital and is a send-up of Grey's Anatomy a medical drama which aired opposite Supernatural in the U.S. on Thursday nights, revolving around the love lives of the staff of Seattle Grace Hospital. Dr. Derek Shepherd, played by Patrick Dempsey, is nicknamed "McDreamy" by other characters on the show.
Dean is a big fan of the show.
The show is first mentioned in 4.18 The Monster at the End of This Book when The Publisher mentions it as one of the reasons the Supernatural books went out of print: "All anybody wants to read anymore is that romance crap. You know -- "Doctor Sexy, M.D."? Please."
In 5.08 Changing Channels, Gabriel traps Sam and Dean in a fantasy realm, where one of the TV shows they are trapped inside is Dr. Sexy, M.D. The scenes and melodramatic dialogue mimic that of Grey's Anatomy - as can be seen in these video clips. Dean picks that Gabriel is disguised as Dr. Sexy because he is wearing the wrong shoes: "The thing that makes Dr. Sexy sexy is the fact that he wears cowboy boots. Not tennis shoes."
In 7.02 Hello, Cruel World one of the Leviathans - Annie - sees a snippet of the show, and that gives it the inspiration to use a hospital as a source of human organs for food. It even refers to itself as a "Doctor Sexy" to assert its authority.