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Croatoan
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[[Image:Croatoan209.jpg|thumb|right|300px350px|Croatoan.]]Croatoan is an ailment specifically described as a "blood-borne {{Quotation|title= |text= '''Dean:''' A demonic virus" that is ?<br>'''Sam:''' Yeah, more like demonic germ warfare.|author= [[demonSam]]ic in origin, and causes a murderous rage in the people it infects[[Dean Winchester]]|source= [[2. 09 Croatoan]]}}
==History==Croatoan is an ailment specifically described as a "blood-borne virus" that is [[demon]]ic in origin, and causes a murderous rage in the people it infects. One legend uncovered by [[John Winchester]] states that the virus was the source of the disappearance of the [[Roanoke Colony]] in 1587. [[Azazel]] field tests the virus in River Grove, Oregon in 2006. It proves effective in causing the townspeople to kill each other, and importantly proves that [[Sam Winchester]] is immune to its effects. It is unknown what happens to the infected, but they were most likely killed by demons as releasing the virus was part of the field test.
Following his release, [[Lucifer]] intends to use this virus to produce chaos and massacre on Earth during the [[Apocalypse]]. The virus is to be distributed by [[Niveus Pharmaceuticals]] in a vaccine that is being used against a swine flu epidemic caused by [[Pestilence]]. The plan is averted when [[Castiel]], [[Sam]], and [[Bobby]] destroy the warehouse where the vaccine is stored.
==Characteristics==
The Croatoan Virus leaves behind traces of [[sulfur]] in the bloodstream after a three hour incubation, after which symptoms begin to surface. Infected people display a murderous rage and a sociopathic change to their personalities, eventually regressing into a more animalistic state and displaying no instinct. They also work together in packs and are able to recognize if someone carries the virus as they only target people who have not been infected. The virus spreads throughout the entire town it's released in and everyone who gets infected disappear within a day, leaving only the survivors, and any possible blood samples taken by the infected victims leave no trace of the virus afterwards. It is unknown if there is a cure for the virus, however people with [[demon blood]] in their system, such as [[Sam Winchester]], are shown to be immune to the virus, showing no traces in his blood steam after five hours following contact.
By the time the [[Apocalypse]] started, [[Pestilence]] and his demons have been working to mutate the virus, causing the infected to display symptoms almost immediately. Unlike previous victims, they display bloodshot eyes and become more feral than average croats, attacking anyone on sight.
==Episodes==
===[[2.09 Croatoan]]===
Following a vision of [[Sam]]'s in which [[Dean]] shoots a man, Sam and Dean travel to River Grove, Oregon. In searching for the man from the vision, they encounter his mother, who is being held by his brother and father, both of whom are overcome with a murderous rage. Sam and Dean save the woman from her son and husband, but it soon becomes clear that she is infected, and Dean kills her. The brothers retreat to a local clinic, where a doctor [[Dr. Amanda Lee]] studies the blood of an infected person and notes that there appears to be traces of [[sulfur]] present, leading Sam to suspect demonic intervention. The virus is transmitted via an exchange of blood, and it takes between three and four hours for symptoms and the sulfur to manifest. The infected show a planning ability and use weapons. They also deliberately infect others.
[[File:CroatoanVirus.jpg|thumb|left|500px350px|The Croatoan virus attacking red blood cells.]]
[[Sam]] speculates that the virus could be related to a theory in [[John's Journal]], that Croatoan - a word they find carved into a telephone pole - is the name of a demon associated with plague and [[Four Horsemen of the Apocalypse|pestilence]]. Sam calls what's going on "demonic germ warfare."
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[[Duane Tanner]], the man [[Sam]] saw in his vision and whose family Sam and [[Dean]] first encountered exhibiting signs of infection, turns up at the medical center. He claims to have been out of town fishing and to have just returned. The medical center occupants suspect he might be infected, and they restrain him by tying him to a chair. Recognizing the scene from his vision, Sam tries to convince Dean not to kill [[Duane Tanner]], as they don't know yet whether he's infected with the virus or not. Dean locks Sam in a room so that he cannot interfere, but Dean is unable to follow through and kill the man. He releases Sam, and they work on an escape plan.
At the end, [[Duane Tanner]] - who is revealed to be [[possessed]] - is shown communicating with [[Azazel]] via a [[goblet of blood]], and reports that "the Winchester boy is immune" (to the virus). Because Sam's vision led them to River Grove, it's implied that this "demon virus" is the work of [[the Yellow-Eyed Demon]].
===[[5.04 The End]]===
[[File:Croatoan504.jpg|right|thumb|300px350px|"Croats" in the [[Alternate Universe|alternate 2014 timeline]].]]In this alternate future, [[Lucifer]] releases the the Croatoan virus in 2012 in order to wipe out humanity. In 2012, the virus started hitting the major cities, causing the human population to drop dramatically. By 2014, many have been infected and diedwhile only a handful of people remain alive. Infected zones are quarantined and the military kills the infected, referred to as "croats" on sight. President Palin orders the bombing of Houston following an outbreak.
In 2014, [[Future!Dean]] leads a small group of survivors, and is trying to locate and recover [[The Colt]] to kill [[Lucifer]]. When one of his men becomes exposed to the virus, he shoots him without warning, later telling Dean that he started recognizing symptoms a half hour prior to his death. When Future!Dean locates Lucifer, [[Future!Castiel]] points out that it's in the middle of a quarantine zone infested with croats. However, no croats appear when they arrive, making Future!Dean realize that the demons cleared a path for them, preparing a trap for the hunters.
===[[5.20 The Devil You Know]]===
Two scientists are discussing the ongoing swine flu epidemic and the vaccine being developed. A [[demon]] possessing a janitor tells them he's seen the vaccine, and that he is running an experiment of his own. He injects a sample of the vaccine into one of the scientists and knocks the other down, then he darts out the door and locks them in the room. The scientist injected with the "vaccine" rises, then attacks and kills the other scientist. The [[demon]] janitor calls someone else, and states that "it works." It is suggested that it is the Croatoan virus, and that the plan for distributing it during the epidemic as a vaccine is the plan of orchestrated by [[Pestilence]] and the his demons'. A demon named [[Brady]], installed at [[Niveus Pharmaceuticals]] is responsible for production.
Unlike the infected in [[2.09 Croatoan]], these victims are immediately overtaken by the virus. They show no higher intelligence, only a fierce anger and drive to attack others. This suggests that the demons have worked to improve the lethality of the virus.
===[[5.21 Two Minutes to Midnight]]===
It is revealed to [[Sam]] and [[Dean]] that [[Niveus Pharmaceuticals]] is distributing a vaccine for the swine flu epidemic, which is actually the Croatoan virus. [[Sam]], [[Castiel]] and [[Bobby]] rush to the warehouse in order to stop the distribution. The [[demon]]s infect a number of human workers in the warehouse in order to stop them, but the infected are quickly dispatched by the joint efforts of [[Sam]], [[Castiel]] and [[Bobby]]. The three of them blow up the warehouseafterwards to destroy all the vaccine and any traces of the virus.
==Trivia==