Antichrist
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In 5.06 I Believe The Children Are Our Future, Castiel corrects the idea that the Antichrist is the son of Satan/Lucifer. The Bible, according to Castiel is wrong, and the Antichrist is not the son of Lucifer, but demon spawn born of humans. They are also known as Cambion. This lineage makes them incredibly powerful and capable of "killing the Host of Heaven with one word". Whether this is literal is not certain. The Anti-Christ gains more power while Lucifer is on Earth.
Jesse Turner is an example of a Cambion.
Links
- Wikipedia entry on the Antichrist
- Catholic Encycolopedia entry on the Antichrist