Antichrist

In 5.06 I Believe The Children Are Our Future, Castiel, corrects the idea that the Anti-Christ is the son of Satan. The Bible, according to Castiel is wrong, and the Anti-Christ is not the son of Lucifer, but demon spawn born of humans. They are also known as Cambion. This lineage makes them incredibly powerful and capable of "killing the Host of Heaven with one word".