* [[4.06 Yellow Fever]] - Sam and Bobby use an iron chain etched with spell work to trap and drag a [[buruburu]] behind the [[Impala]].
* [[5.10 Abandon All Hope...]] - Sam, Dean, and [[Ellen]] build a bomb from propane, salt, and iron nails at [[Jo]]'s insistence to destroy the hellhounds surrounding them.
* [[6.09 Clap Your Hands If You Believe...]] - Sam shoots the [[Leprechaun]] with iron buckshot, weakening him.
* [[6.18 Frontierland]] - The [[phoenix]] was unable to escape from the jail or handcuffs because they were made of iron.