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[[Ruby]] and [[Sam]] stand near a car outside an abandoned house. Sam is upset over the fight with [[Dean]], but when Ruby tells him they can patch things up later, Sam says that there won't be a later, and that he's changed for good.
At Bobby's place, Dean refuses to call Sam. [[Bobby]] calls him out on his behavior, and says he is behaving like [[John Winchester|his father]], in failing to reach out to Sam. Bobby then tells Dean he is a better man than his fatherand begs him not to be like John.
At a hospital, [[Cindy McLellan|Lilith's minion]] is stealing a baby for her to consume. Sam arrives and overpowers her. Back at the abandoned house, he tortures and interrogates her, and she tells him Lilith will be at [[St. Mary's Convent]] in Ilchester, Maryland at midnight the next night. Ruby tells Sam they need to keep the demon alive so Sam can feed on [[Demon Blood|her blood]]to get the power he needs to kill Lilith. The [[demon]] withdraws to the recesses of the possessed girl's mind, so Sam is confronted with an innocent human.
Dean finds himself transported to what appears to be a luxurious hotel room - referred to as the [[Green Room]] by [[Zachariah]]. Zachariah & [[Castiel]] appear and Zachariah says they are keeping him safe in preparation for Lilith breaking the final seal. When he is alone, Dean finally calls Sam and leaves a message apologizing for what he said to him.
Dean pleads with Castiel to let him see Sam, but Castiel refuses. When he confronts Zachariah, the angel finally admits that they don't want to stop Lilith from freeing Lucifer and that the upper echelons of the angels want the Apocalypse to happen in order to defeat [[Hell]] and bring about Paradise on Earth. He also reveals that Dean's role is to kill Lucifer once he has risen.
Later, Castiel returns and apologizes to Dean for deceiving him. Dean is angry and argues with Castiel, trying to convince him to help Dean and Sam stop the Apocalypse. He initially refuses, but then returns and, after cutting himselfhis wrist with [[Ruby's knife]], draws an [[angel banishing sigil]] on the wall with his blood. Zachariah arrives to stop him, Castiel places a bloody hand in the middle of the sigil and Zachariah is sent away. Castiel says he will take Dean to Sam to stop him from killing Lilith - because her death is the final seal.
To find Sam, Castiel and Dean visit [[Chuck Shurley]], who has foreseen that Sam is at the convent. An [[archangel]] arrives, and Castiel says he will hold it off before sending Dean directly to the Convent with a touch of his hand.
At the convent, Lilith and her minions have gathered. Sam and Ruby arrive, and Sam easily dispatches all of the demons and pins Lilith to the altar. Ruby sees Dean arrive and closes the chapel door, efficiently locking him out. Sam starts killing Lilith, but hesitates when he hears Dean shout his name outside the door. When he is taunted by Lilith, his eyes turn black and he ignores Dean's shouting, giving in to killing Lilith.
As Lilith's blood forms a spiral on the chapel floor, Ruby reveals to an appalled Sam that Lilith's death was the final seal and that she has been working to free Lucifer all along, Lilith's personal double agent who none of the other demons knew about, even Alastair. She tells Sam he didn't need the demon blood, that the choices he has made all year have helped him tap into his own power.
Ruby reveals that Sam was the only one who could bring back Lucifer, but before she can say why, Dean finally breaks in and rushes forward. Sam holds Ruby in place as Dean kills her with [[Ruby's Knife|her own knife]].
Suddenly a beam, of light thrusts up from the spiral of Lilith's blood.
