After being taken in by [[Jody Mills]], Annie continued using the name Alex. In 2015, [[Claire Novak]] also moved in with Jody Mills, following the death of her mother. She and Alex developed a slightly fractious sibling relationship, with Alex trying to live a normal life and Claire determined to become a hunter in her own right. After Alex's boyfriend turns out to be a vampire involved in a revenge plot against her, Alex grows closer with Claire, although she tells the Winchesters that she still wants nothing to do with the hunting life.
Alex later gets into nursing, working at Sioux Falls General Hospital. However, she still helps out with hunting from time to time when Jody asks, telling [[Patience Turner]] that while she's not much of a fighter, she still helps as much as she can in other ways. This is shown to include doing monster autopsies and running blood tests on victims for Jody to determine if they are monsters or not. [[Sheriff Donna Hanscum]] later tells Dean that despite her reluctance, Alex has become a competent hunter in her own right.