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While Sam and Dean argue about whether they have to kill the infected or wait until they die, Castiel calls after praying to his angel brothers and sisters to help save him from the spell. He asks if Dean is okay and tells the boys that Rowena fled with the ''[[Book of the Damned]]'' and [[Nadya's Codex]]. Sam asks about the Darkness but Cas doesn't know anything. At that point two angels appear, and Cas tells the Winchesters he may not see them for a while.
As Sam, Dean, and Jenna try to leave the hospital with the baby, Dean reiterates that he wants to shoot their way through, but Sam says they need to stop doing things in the same manner they have historically used. He argues they need to try to focus again on saving people – all the people. He believes they can find a cure for the infected. Dean is initially reluctant but finally agrees to follow Sam's plan. While Dean gets Jenna and the baby out, Sam acts as a decoy to draw the infected away. When Dean and Jenna almost get to the exit door, they are confronted by Mike who, just before he dies, tells them the name of the child, : [[Amara]].
Meanwhile in the suburb, Crowley has summoned two of his minions to pick him up at the woman’s house in the aftermath of the orgy. He resumes possession of his old body, and the minions inform him that the Darkness has been released. Believing that it was only a myth, Crowley shrugs it off, but one of his minions persists, nervously saying that all of hell Hell heard screaming animal sounds from within [[Lucifer's Cage]], as if [[Michael]] or [[Lucifer]] himself was trying to warn [[Hell]] about this incident.
As Sam hides in a supply closet from the rabids, he gets attacked by a nurse who was in the closet with him. He kills her, but infected blood gets in his mouth in the struggle. Within moments, the other rabids break down the door. When they get close to him, however, they sense he is already infected and leave.
