Comic-Con 2015, Jared was asked by MC Richard Speight if the Winchesters would be able to defeat The Darkness, he replied "I think we’ll beat it. Because we’re not the LOSEchesters." Watch it here. When Jared used the "LOSEchesters" line for the fourth time, Jensen quipped back "The thing is we’re slowly turning into the Losechesters!"
Since then Jared has continued to deploy the "Losechesters" at every opportunity, and it is on the way to becoming a comedy classic.