Harley and Sadie
Harley and Sadie (aka Harley Brown and Sadie Lane) were Jared Padalecki's dogs for a large part of the time he worked on Supernatural. Rescued from the same shelter, Harley was a mastiff cross, and Sadie who is 13 months older, is a German Shepherd mix (possibly with some dingo).
In 2006, Harley and Sadie starred along with Jared as part of an anti-fur campaign run by People for the Ethical treatment of Animals (PETA).
Jared supports the L.A. based A Dog's Life Rescue
On Saturday, November 5, 2011, Jared tweeted that Harley had died, having lost a battle with cancer "Can I have 195000 moments of silence 4 a great dog who lost his battle with cancer today? R. I. P. Harley. We're better for having known you" source. There were many tweets of condolence from fans, friends and crew members.
On 3rd March 2016 during a livestream for the one year anniversary of Always Keep Fighting, Jared wished Sadie a happy 13th birthday.
On 3rd March 2017 Jared tweeted "Happy Birthday to two things that bring me great joy :) #Happy14Sadie #Happy2AKF #spnfamily".