|Dates||???? - 2015 (killed by Dean Winchester)|
|Episode(s)|| 10.21 Dark Dynasty|
10.22 The Prisoner
I was wondering if it was best to put such an important assignment in Eldon's hands since his... judgment is so questionable.
– Eli Styne, 10.21 Dark Dynasty
After Eldon is chewed out by his father and given new orders to clean up his mess and find the Winchesters, Eli questions his uncle giving such important tasks, given his questionable judgment. Monroe brings up Eli's own issues, like having shirked his duties in tracking down Charlie Bradbury, a task that was passed on to him after Jacob's death. He orders Eli to report in with Eldon and back his effort before dismissing him.
Eli is able to finally track Charlie down to the Blackbird Motel, and calls his cousin Eldon. Once Eldon arrives at the motel, Eli hangs back as his cousin goes to confront Charlie in her motel room.
As Cyrus Styne leaves school, he is accosted by a bully, but stands up to the bully by making fun him. When the bully retaliates by knocking down Cyrus, it prompts Cyrus's cousin Eli to intervene. However Cyrus lies to his cousin about there being a problem and leaves. Some time later Eli follows the bully and kidnaps him for laying hands on his cousin, the bully is brought to the Styne family home by Eli, where he is to be Cyrus' first harvest.
When Dean locates the Styne family home, he is ambushed by Eli who knocks him out by suffocating him with a plastic bag. When Dean comes to, strapped to a table in the operating room, he warns Eli and Monroe that the Mark of Cain won't let him, die and if he does die he will be brought back as a demon and kill everyone. Undeterred by this info, Eli continues to mock Dean. Until Dean is able to break free of the restraints and slashes Eli's throat, killing him.